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Case Series
Clustering of Familial pancreatic adenocarcinoma in a family from Sudan
1 Consultant Physician of Internal Medicine and Medical Oncology, Ambulatory Medicine, Hamad, Medical Corporation, Doha-State of Qatar
2 Pre-college Volunteer Student at London Central Secondary School, Applicant for Medical School at Weill Cornell-Qatar (WCM-Q)
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M. S. Ahmed
Consultant Physician of Internal Medicine and Medical Oncology/Ambulatory Medicine, Hamad Medical Corporation, P.O. Box - 3050,
Doha-State of Qatar
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Article ID: 100008C01MA2018
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How to cite this article
Ahmed MS, Sadiq YM. Clustering of Familial pancreatic adenocarcinoma in a family from Sudan. Edorium J Cancer 2018;4:100008C01MA2018.ABSTRACT
Introduction: Pancreatic cancer (PC) is an aggressive and rapidly progressive malignancy with a 5-year survival rate of approximately 5%. Of all pancreatic cancers, 80% are adenocarcinomas of the ductal epithelium and only 2% of tumors of the exocrine pancreas are benign. On first diagnosis, half of patients found to have distant disease and half of the rest are locally advanced. Many genetic factors, hereditary syndromes, and lack of screening programs contributed to the behavior of PC.
Case Series: We report familial pancreatic cancer in four members of the same family, two brothers diagnosed to have pancreatic cancer at their fifth decade of age. Previously their sister was diagnosed with adenocarcinoma of the cecum at fifth decade, and their mother died of colorectal cancer at old age. The presentation of the three siblings were similar in term of tumor markers, as CA 19–9 (tumor marker of pancreatic cancer) was within normal limits at diagnosis in all three patients, but CEA was slightly more than normal and their lower endoscopies showed no colorectal polyps but diverticulosis. The histological diagnosis of both brothers with PC was poorly-differentiated adenocarcinoma of the pancreas. This is a first report from Qatar describing this rare clinical entity.
Conclusion: Familial pancreatic cancer would behave similar to pancreatic cancer in clinical context but it may be easy to screen for bearing in mind its behavior to affect many individuals in the same family; especially if we can find the underlying precursors to explain its pathophysiology. The aim of this article is to increase physicians’ awareness of this clinical entity.
Keywords: Familial pancreatic cancer, Pancreatic cancer, Screening
SUPPORTING INFORMATION
Author Contributions
M. S. Ahmed - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Y. M. Sadiq - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this case series.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2018 M. S. Ahmed et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
