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Original Article
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| A retrospective study of 53 cases of primary tumors of the pleura diagnosed over a 16-year period | ||||||
| Mona Mlika1, Aida Ayadi-Kaddour1, Beya Chelly2, Sadok Boudaya3, Saoussen Maalej4, Tarek Kilani3, Faouzi El Mezni2 | ||||||
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1Research Unit of Prof El Mezni: 02-UR-08/08. Department of Pathology, Abderrahman Mami Hospital, University of Medicine. Bad Saadoun. Tunis. Tunisia.
2Department of Pathology, Abderrahman Mami Hospital, University of Medicine. Bad Saadoun, Tunis, Tunisia. 3Department of Thoracic Surgery. Abderrahman Mami Hospital, University of Medicine. Bad Saadoun, Tunis, Tunisia. 4Department of Pulmonology, Abderrahman Mami Hospital, University of Medicine. Bad Saadoun, Tunis, Tunisia. | ||||||
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| Mlika M, Ayadi-Kaddour A, Chelly B, Boudaya S, Maalej S, Kilani T, Mezni FE. A retrospective study of 53 cases diagnosed over a 16-year period: Our experience of primary tumors of the pleura. Edorium Journal of Cancer 2013;1:1–7. |
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Abstract
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Aims
Primary tumors of the pleura are rare, representing only 10% of the pleural tumors. These tumors are represented mainly by malignant pleural mesothelioma. Our aim is to describe the clinical, histologic and radiologic features of the most relevant primary pleural tumors. Besides, we searched to put emphasis on their challenging diagnosis and management.
Methods We describe a study of 53 cases of primary tumors of the pleura diagnosed in the Department of Pathology in the Abderrahman Mami Hospital over a 16-year period from 1995 to 2011. Results Our study included 37 men and 16 women with a mean age of 57.5 years (range 22 to 72 years). Microscopic findings concluded to malignant pleural mesothelioma in 31 cases, solitary fibrous tumors in 19 cases, and one case each in synovial sarcoma, primary pleural thymoma, and calcifying pseudo-tumor. Inspite of the importance of the radiologic findings, the definitive diagnosis was based on histologic, immunohistochemical findings and FISH technique. The management of the patients was variable. Those with malignant and limited tumors received a multimodal therapy associating surgical resection, chemotherapy and radiation therapy. Benign tumors including benign forms of solitary fibrous tumors and calcifying pseudo-tumor were treated surgically and presented no complications. Conclusion: The primary tumors of the pleura are challenging in their diagnosis because of the multiplicity of mimickers. Besides, their management remains non consensual due to the rarity of clinical data but surgical procedures seem to play a key role not only in enabling their excision but also by providing a definitive diagnosis thanks to surgical biopsies. | |
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Key Words:
Primary pleural tumors, Malignant pleural mesothelioma, Solitary fibrous tumors
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Author Contributions:
Mona Mlika - Substantial contributions to conception and design, Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Aida Ayadi-Kaddour - Substantial contributions to conception and design, Analysis and interpretation of data, Drafting the article, Final approval of the version to be published Beya Chelly- Substantial contributions to conception and design, Drafting the article, revising it critically for important intellectual content, Final approval of the version to be published Sadok Boudaya - Contribution to interpretation of data, Drafting the article, Final approval of the revised version Saoussen Maalej - Interpretation of data, Drafting the article, Final approval of the final version Tarek Kilani - Interpretation of data, Drafting the article, Final approval of article Faouzi Mezni - Interpretation of data, Drafting manuscript, Final approval of the definite version |
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Guarantor of submission:
The corresponding author is the guarantor of submission. |
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Source of support:
None |
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Conflict of interest:
Authors declare no conflict of interest. |
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Copyright:
© Mona Mlika et al. 2013; This article is distributed the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any means provided the original authors and original publisher are properly credited. (Please see Copyright Policy for more information.) |
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